ACLS Drug References

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• Adenosine:
• 6-12-12 mg iv push with saline flush q 5 min.
• SE: Atrial fibrillation, dyspnea, chest discomfort.
• Amiodarone:
• Non-cardiac arrest: load 15 mg/min over 10 min then 1 mg/min x 6 hrs (mix 900 mg in 500 cc D5W)  then 0.5 mg/min x 18 hrs and beyond; supplemental bolus: 15 mg/min x 10 min.
• Cardiac arrest:  300 mg iv push, can consider repeat 150 mg iv once.
• Atropine:
• 0.5-1 mg to 0.04 mg/kg (e.g. 3mg).
• Epinephrine:
• 1 mg q3-5 min iv during CPR.
• Diltiazem:
• 0.25mg/kg (e.g. 20 mg over 2 min) then 0.35mg/kg (e.g. 25 mg over 2 min); infuse 5-15 mg per hour.
• Dofetilide:
• 250 mcg bid po (CrCl 40-60 ml/min); 250 mcg qd (crCl 20-40 ml/min)  "Prescriber requires certification by manufacturer".
• Ibutilde:
• >60 kg 1 mg.
• <60 kg 0.01 mg/kg over 10 min.
• May repeat x 1.
• Make sure K>4.0 and Mg normal.
• Not recommended for low EF.
• Lidocaine:
• 1 mg/kg bolus, 0.5 mg/kg q8-10 min, max 3 mg/kg. Then infuse 1-4 mg/min.
• SE: paraesthesia, seizure, confusion.
• Magnesium sulfate:
• 1-2g over 5-60 min.
• Procainamide:
• 20 mg/min up to 17 mg/kg (1000 mg), then infuse 1-4 mg/min.
• SE: hypotension, torsade
• Vasopressin:
• 40 IU x 1 dose only (for pulseless VT/VF).
• Verapamil:
• 2.5-5-10 mg bolus, slowly.